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PLoS One. 2013 Dec 20;8(12):e83297. doi: 10.1371/journal.pone.0083297. eCollection 2013.

The frontal eye field is involved in visual vector inversion in humans--a theta burst stimulation study.

Author information

1
Perception and Eye Movement Laboratory, Departments of Neurology and Clinical Research, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
2
Perception and Eye Movement Laboratory, Departments of Neurology and Clinical Research, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland ; Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.
3
Perception and Eye Movement Laboratory, Departments of Neurology and Clinical Research, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland ; Centre of Neurology and Neurorehabilitation, Luzerner Kantonsspital, Luzern, Switzerland.

Abstract

In the antisaccade task, subjects are requested to suppress a reflexive saccade towards a visual target and to perform a saccade towards the opposite side. In addition, in order to reproduce an accurate saccadic amplitude, the visual saccade vector (i.e., the distance between a central fixation point and the peripheral target) must be exactly inverted from one visual hemifield to the other. Results from recent studies using a correlational approach (i.e., fMRI, MEG) suggest that not only the posterior parietal cortex (PPC) but also the frontal eye field (FEF) might play an important role in such a visual vector inversion process. In order to assess whether the FEF contributes to visual vector inversion, we applied an interference approach with continuous theta burst stimulation (cTBS) during a memory-guided antisaccade task. In 10 healthy subjects, one train of cTBS was applied over the right FEF prior to a memory-guided antisaccade task. In comparison to the performance without stimulation or with sham stimulation, cTBS over the right FEF induced a hypometric gain for rightward but not leftward antisaccades. These results obtained with an interference approach confirm that the FEF is also involved in the process of visual vector inversion.

PMID:
24376682
PMCID:
PMC3869760
DOI:
10.1371/journal.pone.0083297
[Indexed for MEDLINE]
Free PMC Article

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