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Clin Dev Immunol. 2013;2013:464039. doi: 10.1155/2013/464039. Epub 2013 Nov 27.

Immune response to mycobacterial infection: lessons from flow cytometry.

Author information

1
Intensive Care Unit, 1st Department of Respiratory Medicine, Medical School, National and Kapodistrian University of Athens and "Sotiria" Chest Disease Hospital, 152 Mesogeion Avenue, 11527 Athens, Greece.
2
3rd Department of Pulmonology, Sismanoglio General Hospital, 15126 Athens, Greece.
3
1st Department of Respiratory Medicine, Medical School, National and Kapodistrian University of Athens and "Sotiria" Chest Disease Hospital, 11527 Athens, Greece.

Abstract

Detecting and treating active and latent tuberculosis are pivotal elements for effective infection control; yet, due to their significant inherent limitations, the diagnostic means for these two stages of tuberculosis (TB) to date remain suboptimal. This paper reviews the current diagnostic tools for mycobacterial infection and focuses on the application of flow cytometry as a promising method for rapid and reliable diagnosis of mycobacterial infection as well as discrimination between active and latent TB: it summarizes diagnostic biomarkers distinguishing the two states of infection and also features of the distinct immune response against Mycobacterium tuberculosis (Mtb) at certain stages of infection as revealed by flow cytometry to date.

PMID:
24376464
PMCID:
PMC3860082
DOI:
10.1155/2013/464039
[Indexed for MEDLINE]
Free PMC Article

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