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Bioinformatics. 2014 Feb 15;30(4):588-9. doi: 10.1093/bioinformatics/btt718. Epub 2013 Dec 28.

HTS navigator: freely accessible cheminformatics software for analyzing high-throughput screening data.

Author information

1
Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill and Department of Pharmacology and the NIMH Psychoactive Drug Screening Program, School of Medicine, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA.

Abstract

SUMMARY:

We report on the development of the high-throughput screening (HTS) Navigator software to analyze and visualize the results of HTS of chemical libraries. The HTS Navigator processes output files from different plate readers' formats, computes the overall HTS matrix, automatically detects hits and has different types of baseline navigation and correction features. The software incorporates advanced cheminformatics capabilities such as chemical structure storage and visualization, fast similarity search and chemical neighborhood analysis for retrieved hits. The software is freely available for academic laboratories.

AVAILABILITY AND IMPLEMENTATION:

http://fourches.web.unc.edu/

PMID:
24376084
PMCID:
PMC3928525
DOI:
10.1093/bioinformatics/btt718
[Indexed for MEDLINE]
Free PMC Article
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