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Wiley Interdiscip Rev RNA. 2014 May-Jun;5(3):335-46. doi: 10.1002/wrna.1214. Epub 2013 Dec 16.

Battle against RNA oxidation: molecular mechanisms for reducing oxidized RNA to protect cells.

Author information

1
Department of Biomedical Science, Florida Atlantic University, Boca Raton, FL, USA.

Abstract

Oxidation is probably the most common type of damage that occurs in cellular RNA. Oxidized RNA may be dysfunctional and is implicated in the pathogenesis of age-related human diseases. Cellular mechanisms controlling oxidized RNA have begun to be revealed. Currently, a number of ribonucleases and RNA-binding proteins have been shown to reduce oxidized RNA and to protect cells under oxidative stress. Although information about how these factors work is still very limited, we suggest several mechanisms that can be used to minimize oxidized RNA in various organisms.

PMID:
24375979
PMCID:
PMC3991771
DOI:
10.1002/wrna.1214
[Indexed for MEDLINE]
Free PMC Article

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