PEGylated WS(2) nanosheets as a multifunctional theranostic agent for in vivo dual-modal CT/photoacoustic imaging guided photothermal therapy

Adv Mater. 2014 Mar 26;26(12):1886-93. doi: 10.1002/adma.201304497. Epub 2013 Dec 23.

Abstract

A new generation of photothermal theranostic agents is developed based on PEGylated WS2 nanosheets. Bimodal in vivo CT/photoacoustic imaging reveals strong tumor contrast after either intratumoral or intravenous injection of WS2 -PEG. In vivo photothermal treatment is then conducted in a mouse tumor model, achieving excellent therapeutic efficacy with complete ablation of tumors. This work promises further exploration of transition-metal dichalcogenides for biomedical applications, such as cancer imaging and therapy.

Keywords: CT imaging; PAT imaging; Photothermal therapy; WS2 nanosheet.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line
  • Cell Line, Tumor
  • Cell Survival
  • Female
  • HeLa Cells
  • Humans
  • Hyperthermia, Induced
  • Mammary Neoplasms, Animal / pathology
  • Mammary Neoplasms, Animal / therapy
  • Materials Testing
  • Mice
  • Mice, Inbred BALB C
  • Nanostructures* / adverse effects
  • Nanostructures* / chemistry
  • Neoplasm Transplantation
  • Phototherapy / methods*
  • Polyethylene Glycols* / adverse effects
  • Polyethylene Glycols* / chemistry
  • Tomography, X-Ray Computed
  • Treatment Outcome
  • Tungsten Compounds* / adverse effects
  • Tungsten Compounds* / chemistry

Substances

  • Tungsten Compounds
  • Polyethylene Glycols