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Spectrochim Acta A Mol Biomol Spectrosc. 2014;121:719-23. doi: 10.1016/j.saa.2013.11.099. Epub 2013 Dec 8.

The phase-resolved photoacoustic method to indicate chemical assignments of paracetamol.

Author information

1
Departamento de Ciências Farmacêuticas, Universidade Estadual de Ponta Grossa, Av. General Carlos Cavalcanti 4748,CEP 84030-900 Ponta Grossa, PR, Brazil.
2
Departamento de Física, Universidade Estadual de Ponta Grossa, Av. General Carlos Cavalcanti 4748, CEP 84030-900 Ponta Grossa, PR, Brazil.
3
Departamento de Física, Universidade Estadual de Maringá, Av. Colombo 5790, 87020-900 Maringá, PR, Brazil.
4
Departamento de Física, Universidade Estadual de Ponta Grossa, Av. General Carlos Cavalcanti 4748, CEP 84030-900 Ponta Grossa, PR, Brazil. Electronic address: anovatski2@gmail.com.

Abstract

In this work, the phase-resolved photoacoustic method was applied to provide specific information on the chemical assignments of paracetamol in the near-infrared region. Two broad bands, centered at 1370 and 1130 nm, were well-resolved using this method, making it possible to assign the peaks centered at 1398, 1355 and 1295 nm to a C-H combination from a CH3 structure and the peak at 1305 nm to a C-H combination from the aromatic ring. This information represents a new finding in chemical studies regarding this medicament.

KEYWORDS:

NIR; Paracetamol; Phase-resolved photoacoustic

PMID:
24374885
DOI:
10.1016/j.saa.2013.11.099
[Indexed for MEDLINE]
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