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Clin Chim Acta. 2014 Feb 15;429:206-11. doi: 10.1016/j.cca.2013.12.019. Epub 2013 Dec 25.

Mannose-binding lectin deficiency is not associated with anti-Saccharomyces cerevisiae antibody in Korean Crohn's disease patients.

Author information

1
Department of Internal Medicine, Seoul Paik Hospital, Inje University College of Medicine, 85 Geo-dong, Jung-gu, Seoul 100-032, South Korea. Electronic address: yousunk69@korea.com.
2
Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong Gangnam-gu, Seoul 135-710, South Korea. Electronic address: younghokim@skku.edu.
3
Department of Internal Medicine, University of Ulsan College of Medicine, 388 Pungnap-dong, Songpa-gu, Seoul, 138-746, South Korea.
4
Department of Internal Medicine, Seoul Paik Hospital, Inje University College of Medicine, 85 Geo-dong, Jung-gu, Seoul 100-032, South Korea.
5
Department of Internal Medicine, Seoul National University College of Medicine, 101 Deahang-no, Jongno-gu, Seoul, 110-744, South Korea.
6
Department of Internal Medicine, Hanyang University College of Medicine, 249 Kyomun-dong, Kuri, 471-701, South Korea.

Abstract

BACKGROUND:

Mannose-binding lectin (MBL) is a pattern-recognition molecule and an important component of the innate defense system. Anti-Saccharomyces cerevisiae antibody (ASCA) is a well known serologic marker of Crohn's disease (CD). This study aimed to investigate the association between MBL, ASCA, and clinical features in Korean CD patients.

METHOD:

Two hundred and eighty-three well-characterized CD patients were included. MBL concentrations, serum IgG and IgA concentrations of ASCA were determined by ELISA. Low MBL concentrations were defined as serum MBL concentrations <500 ng/ml.

RESULT:

Low MBL concentrations were observed in 41 CD patients (14.5%). No differences in MBL concentrations were detected according to the age at diagnosis, behavior, or the location of patients with CD. MBL concentrations and the frequency of low MBL concentrations did not differ according to ASCA positivity. The presence of perianal involvement (p=0.043), younger age at diagnosis (p=0.021), and intestinal surgery (p=0.047) were more frequently associated with ASCA positive patients.

CONCLUSION:

MBL concentration is not associated with clinical features of CD patients or ASCA positivity. ASCA positivity is associated with a severe clinical course in Korean CD patients.

KEYWORDS:

ASCA; Anti-Saccharomyces cerevisiae antibody; CD; Crohn's disease; MBL; Mannose-binding lectin; anti-Saccharomyces cerevisiae antibody; mannose-binding lectin

PMID:
24374090
DOI:
10.1016/j.cca.2013.12.019
[Indexed for MEDLINE]
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