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Clin Neurophysiol. 2014 Jul;125(7):1407-16. doi: 10.1016/j.clinph.2013.11.031. Epub 2013 Dec 7.

Effects of mindfulness-based cognitive therapy on neurophysiological correlates of performance monitoring in adult attention-deficit/hyperactivity disorder.

Author information

1
Faculty of Science, Intelligent Systems, Radboud University Nijmegen, The Netherlands; Radboud University Nijmegen Medical Centre, Department of Cognitive Neuroscience, Nijmegen, The Netherlands. Electronic address: schoenberg@scientist.com.
2
Department of Psychiatry, Radboud University Medical Centre, Nijmegen, The Netherlands.
3
Faculty of Science, Intelligent Systems, Radboud University Nijmegen, The Netherlands.
4
Department of Psychiatry, Radboud University Medical Centre, Nijmegen, The Netherlands; Radboud University Nijmegen Medical Centre, Department of Cognitive Neuroscience, Nijmegen, The Netherlands.

Abstract

OBJECTIVE:

To examine whether mindfulness-based cognitive therapy (MBCT) would enhance attenuated amplitudes of event-related potentials (ERPs) indexing performance monitoring biomarkers of attention-deficit/hyperactivity disorder (ADHD).

METHODS:

Fifty adult ADHD patients took part in a randomised controlled study investigating ERP and clinical measures pre-to-post MBCT. Twenty-six patients were randomly allocated to MBCT, 24 to a wait-list control. Main outcome measures included error processing (ERN, Pe), conflict monitoring (NoGo-N2), and inhibitory control (NoGo-P3) ERPs concomitant to a continuous performance task (CPT-X). Inattention and hyperactivity-impulsivity ADHD symptoms, psychological distress and social functioning, and mindfulness skills were also assessed.

RESULTS:

MBCT was associated with increased Pe and NoGo-P3 amplitudes, coinciding with reduced 'hyperactivity/impulsivity' and 'inattention' symptomatology. Specific to the MBCT; enhanced Pe amplitudes correlated with a decrease in hyperactivity/impulsivity symptoms and increased 'act-with-awareness' mindfulness skill, whereas, enhanced P3 correlated with amelioration in inattention symptoms.

CONCLUSIONS:

MBCT enhanced ERP amplitudes associated with motivational saliency and error awareness, leading to improved inhibitory regulation.

SIGNIFICANCE:

MBCT suggests having comparable modulation on performance monitoring ERP amplitudes as pharmacological treatments. Further study and development of MBCT as a treatment for ADHD is warranted, in addition to its potential scope for clinical applicability to broader defined externalising disorders and clinical problems associated with impairments of the prefrontal cortex.

KEYWORDS:

Attention-deficit/hyperactivity disorder (ADHD); Event-related potential (ERP); Mindfulness-based cognitive therapy (MBCT); Performance monitoring system

PMID:
24374088
DOI:
10.1016/j.clinph.2013.11.031
[Indexed for MEDLINE]

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