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Hum Immunol. 2014 Mar;75(3):203-7. doi: 10.1016/j.humimm.2013.12.013. Epub 2013 Dec 27.

Association between interleukin-10 -1082A/G, -819C/T and -592C/A polymorphisms with deep venous thrombosis.

Author information

1
Department of Vascular Surgery, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, PR China.
2
Department of Vascular Surgery, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, PR China. Electronic address: jianmingsun@live.cn.

Abstract

BACKGROUND:

Deep venous thrombosis (DVT) and inflammation are two closely related entities. The objective of this study was to evaluate a possible association between interleukin-10 (IL-10) -1082A/G, -819C/T and -592C/A polymorphisms with DVT.

METHODS:

A case-control study was carried out in 660 patients with DVT and 660 age- and gender-matched healthy controls. Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay was applied to identify the polymorphisms mentioned.

RESULTS:

Patients with DVT had a significantly lower frequency of IL-10 -1082GG genotype [odds ratio (OR)=0.59, 95% confidence interval (CI)=0.39, 0.89; P=0.01] than healthy controls. When stratifying by family history of DVT, it was found that patients with positive family history of DVT had a significantly lower frequency of IL-10 -1082GG genotype (OR=0.13, 95% CI=0.02, 0.95; P=0.04). When stratifying by smoking status, presence of varicose veins, type 2 diabetes mellitus and any hormone administration before, no significant differences were found in any groups.

CONCLUSIONS:

This study provides evidence that IL-10 -1082A/G polymorphism associated with risk of DVT. However, no association of the IL-10 -592C/A or -819C/T polymorphism with DVT risk was found. Additional well-designed large studies were required for the validation of our results.

PMID:
24374045
DOI:
10.1016/j.humimm.2013.12.013
[Indexed for MEDLINE]
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