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Mech Ageing Dev. 2014 Mar-Apr;136-137:70-5. doi: 10.1016/j.mad.2013.12.004. Epub 2013 Dec 25.

Maintenance of a healthy trajectory of the intestinal microbiome during aging: a dietary approach.

Author information

1
Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy. Electronic address: marco.candela@unibo.it.
2
Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.
3
Department of Microbiology & Alimentary Pharmabiotic Centre, University College Cork, Ireland.
4
Laboratory of Microbiology, Wageningen University, The Netherlands, and Departments of Veterinary Biosciences and Bacteriology & Immunology, Helsinki University, Finland.

Abstract

Sharing an intense transgenomic metabolism with the host, the intestinal microbiota is an essential factor for several aspects of the human physiology. However, several age-related factors, such as changes diet, lifestyle, inflammation and frailty, force the deterioration of this intestinal microbiota-host mutualistic interaction, compromising the possibility to reach longevity. In this scenario, the NU-AGE project involves the development of dietary interventions specifically tailored to the maintenance of a healthy trajectory of the intestinal microbiome, counteracting all processes connected to the pathophysiology of the human aging.

KEYWORDS:

Diet; Frailty; Healthy aging; Inflammation; Intestinal microbiota

PMID:
24373997
DOI:
10.1016/j.mad.2013.12.004
[Indexed for MEDLINE]

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