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J Sci Med Sport. 2015 Jan;18(1):8-12. doi: 10.1016/j.jsams.2013.11.008. Epub 2013 Nov 28.

Oral contraception does not alter typical post-exercise interleukin-6 and hepcidin levels in females.

Author information

1
School of Sport Science, Exercise and Health, The University of Western Australia, Australia. Electronic address: marc.sim@uwa.edu.au.
2
School of Sport Science, Exercise and Health, The University of Western Australia, Australia.
3
Department of Laboratory Medicine, Laboratory of Genetic, Endocrine and Metabolic diseases, Radboud University Medical Centre, The Netherlands.
4
School of Medicine and Pharmacology, The University of Western Australia, Fremantle Hospital, Australia.
5
School of Medicine and Pharmacology, The University of Western Australia, Fremantle Hospital, Australia; Western Australian Institute for Medical Research, Australia.

Abstract

OBJECTIVES:

The post-exercise interleukin-6 (IL-6) and hepcidin response was investigated during the hormone-deplete and hormone-replete phases of an estradiol and progestogen regulated oral contraceptive cycle (OCC).

DESIGN:

Counterbalanced, repeated measures cross-over study.

METHODS:

Ten active female monophasic oral contraceptive pill (OCP) users completed two 40 min treadmill running trials at 75% of their pre-determined peak oxygen uptake velocity (vVO2peak). These trials were randomly performed in two specific phases of the OCC: (a) Day 2-4, representing a hormone-free withdrawal period (D-0); (b) Day 12-14, representing the end of the first week of active hormone therapy (D+7). Venous blood samples were drawn pre-, post- and 3h post-exercise.

RESULTS:

In both trials, serum IL-6 was significantly elevated (p<0.05) immediately post-exercise, while serum hepcidin was significantly elevated (p<0.05) 3h post-exercise, with no significant differences recorded between trials.

CONCLUSIONS:

These findings suggest that exercise performed during the different phases (D-0 vs. D+7) of a monophasic OCP regulated cycle does not alter exercise induced IL-6 or hepcidin production. As such, future studies looking to investigate similar variables post-exercise, may not need to 'control' for different phases of the OCC, provided participants are current monophasic OCP users.

KEYWORDS:

Iron deficiency; Oestrogen; Progesterone; Running

PMID:
24373771
DOI:
10.1016/j.jsams.2013.11.008
[Indexed for MEDLINE]

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