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J Child Psychol Psychiatry. 2014 Jun;55(6):615-31. doi: 10.1111/jcpp.12187. Epub 2013 Dec 23.

Annual research review: The neuroinflammation hypothesis for stress and psychopathology in children--developmental psychoneuroimmunology.

Author information

1
University of Rochester Medical Center, Rochester, NY, USA.

Abstract

Experimental animal and adult human data suggest that stress exposure is associated with alterations in immune system function that may underlie increased susceptibility to disease and behavioral disorders. The implications of these data for child psychology and psychiatry are not yet clear. The current review seeks to distil and translate the relevant animal and adult human work to children to advance a developmental model of psychoneuroimmunology. In addition to reviewing key specific findings, we consider biological/conceptual models and technical aspects of psychoneuroimmunology work in pediatric populations, and outline the rationales and advantages of integrating hypotheses concerning neuroinflammation in developmental studies of psychopathology.

KEYWORDS:

Immunology; developmental psychopathology; neuroinflammation; psychoneuroimmunology; stress

PMID:
24372371
PMCID:
PMC4029900
DOI:
10.1111/jcpp.12187
[Indexed for MEDLINE]
Free PMC Article

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