Format

Send to

Choose Destination
J Perinatol. 2014 Mar;34(3):203-8. doi: 10.1038/jp.2013.162. Epub 2013 Dec 26.

Outcomes of extremely preterm infants following severe intracranial hemorrhage.

Author information

1
Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University, Palo Alto, CA, USA.
2
Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Duke University Medical Center, Durham, NC, USA.
3
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
4
Statistics and Epidemiology Unit, RTI International, Research Triangle Park, NC, USA.
5
Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
6
Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
7
Department of Pediatrics, Wayne State University, Detroit, MI, USA.
8
Department of Pediatrics, Brown University, Providence, RI, USA.
9
Department of Pediatrics, Case Western Reserve University, Cleveland, OH, USA.
10
Statistics and Epidemiology Unit, RTI International, Rockville, MD, USA.
11
Pregnancy and Perinatology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.

Abstract

OBJECTIVE:

Severe intracranial hemorrhage (ICH) is an important prognostic variable in extremely preterm (EPT) infants. We examined imaging and clinical variables that predict outcomes in EPT infants with severe ICH.

STUDY DESIGN:

Retrospective analysis of 353 EPT infants with severe ICH. Outcomes were compared by examining: (i) unilateral vs bilateral ICH; and (ii) presence vs absence of hemorrhagic parenchymal infarction (HPI). Regression analyses identified variables associated with death or neurodevelopmental impairment (NDI).

RESULT:

Bilateral ICH and HPI had higher rates of adverse outcomes and were independently associated with death/NDI. HPI was the most important variable for infants of lower birth weight, and bilateral ICH for larger infants. For infants surviving to 36 weeks, shunt placement was most associated with death/NDI.

CONCLUSION:

Bilateral ICH and the presence of HPI in EPT infants with severe ICH are associated with death/NDI, though the importance depends on birth weight and survival to 36 weeks.

PMID:
24370654
PMCID:
PMC4143234
DOI:
10.1038/jp.2013.162
[Indexed for MEDLINE]
Free PMC Article

Publication type, MeSH terms, Grant support

Publication type

MeSH terms

Grant support

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center