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ACS Nano. 2014 Jan 28;8(1):495-502. doi: 10.1021/nn405012h. Epub 2014 Jan 2.

Size-controlled self-assembly of superparamagnetic polymersomes.

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1
Department of Chemistry, University of Pennsylvania , 231 S. South 34th Street, Philadelphia, Pennsylvania 19104, United States.

Abstract

We report the size-controlled self-assembly of polymersomes through the cooperative self-assembly of nanoparticles and amphiphilic polymers. Polymersomes densely packed with magnetic nanoparticles in the polymersome membrane (magneto-polymersome) were fabricated with a series of different sized iron oxide nanoparticles. The distribution of nanoparticles in a polymersome membrane was size-dependent; while small nanoparticles were dispersed in a polymer bilayer, large particles formed a well-ordered superstructure at the interface between the inner and outer layer of a bilayer membrane. The yield of magneto-polymersomes increased with increasing the diameter of incorporated nanoparticles. Moreover, the size of the polymersomes was effectively controlled by varying the size of incorporated nanoparticles. This size-dependent self-assembly was attributed to the polymer chain entropy effect and the size-dependent localization of nanoparticles in polymersome bilayers. The transverse relaxation rates (r2) of magneto-polymersomes increased with increasing the nanoparticle diameter and decreasing the size of polymersomes, reaching 555 ± 24 s(-1) mM(-1) for 241 ± 16 nm polymersomes, which is the highest value reported to date for superparamagnetic iron oxide nanoparticles.

PMID:
24369711
PMCID:
PMC5540317
DOI:
10.1021/nn405012h
[Indexed for MEDLINE]
Free PMC Article
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