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Clin Calcium. 2014 Jan;24(1):59-67. doi: CliCa14015967.

[Reducing bone resorption by cathepsin K inhibitor and treatment of osteoporosis].

[Article in Japanese]

Author information

1
Third Department of Medicine, Teikyo University Chiba Medical Center, Japan.

Abstract

Cathepsin K is a lysosomal cysteine protease, secreted from osteoclasts. It plays a major role in the osteoclastic bone resorption by cleaving type 1 collagen, the major bone matrix protein, under acidic pH. In cathepsin K knockout mice, bone mineral density (BMD) is increased, bone resorption is decreased without reduction in the number of osteoclast whereas bone formation is decreased. Based on these results, cathepsin K inhibitors have been developed for the treatment of osteoporosis. Odanacatib is one of them and is perhaps closest for launching. In phase 1 and 2 trials, it markedly reduced bone resorption with a transient reduction in bone formation, thus resulted in a robust increase in both trabecular and cortical BMD in osteoporotics. Currently, Odanacatib is in phase 3 fracture prevention trial, of which results are anticipated in 2014.

PMID:
24369281
DOI:
CliCa14015967
[Indexed for MEDLINE]
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