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J Gerontol A Biol Sci Med Sci. 2014 Aug;69(8):1025-32. doi: 10.1093/gerona/glt206. Epub 2013 Dec 24.

Insulin-like growth factor I, insulin-like growth factor binding protein 3, and atrial fibrillation in the elderly.

Author information

1
Department of Geriatrics, AP-HP, Broca Hospital, Paris, France. Université Paris Descartes, Sorbonne Paris Cité, EA 4468, Paris, France. INSERM, UMR-S894, Centre de Psychiatrie et Neuroscience, Paris, France. emmanuelle.duron@brc.aphp.fr.
2
Department of Geriatrics, AP-HP, Broca Hospital, Paris, France. Université Paris Descartes, Sorbonne Paris Cité, EA 4468, Paris, France.
3
INSERM, UMR-S894, Centre de Psychiatrie et Neuroscience, Paris, France.
4
IINSERM, UMRS. 938, Centre de Recherche St-Antoine, Paris, France.
5
Université Paris Descartes, Sorbonne Paris Cité, EA 4468, Paris, France. Unite d'Epidemiologie et de Biostatistique, Hotel Dieu, Paris, France.
6
Department of Geriatrics, AP-HP, Broca Hospital, Paris, France. Université Paris Descartes, Sorbonne Paris Cité, EA 4468, Paris, France. emmanuelle.duron@brc.aphp.fr.

Abstract

BACKGROUND:

Insulin-like growth factor I (IGF-I) and insulin-like growth factor binding protein 3 (IGFBP-3) are involved in oxidative stress and atherosclerosis; however, the relationship between the IGF-I system and atrial fibrillation (AF) is not known. The objective of this analysis was to assess, the relationship between IGF-I and IGFBP-3 serum levels and AF among elderly participants.

METHODS:

In this cross-sectional study, 719 participants (mean age [SD] years: 78.2 [6.8]; 31.8% men) were evaluated during an outpatient geriatric assessment. AF was determined by electrocardiogram or medical record. Participants were classified into two groups: Participants with AF (n = 91) or without AF (n = 628). IGF-I and IGFBP-3 serum levels were determined by enzyme linked immunosorbent assay.

RESULTS:

After adjusting for age and sex, the mean IGF-I and IGFBP-3 serum levels were significantly lower among AF participants than among non-AF participants (mean IGF-I ng/mL [SD] = 133.8 [66.6] vs 157.9 [80.0], p = .02; mean IGFBP-3 ng/mL [SD] = 3,653 [1,393] vs 4,151 [1,583], p = .03, respectively). After adjusting for confounding factors (age, gender, beta blocker medication, heart rate, hypertension, stroke, and chronic heart failure), low IGF-I serum level (OR [95% CI] = 0.66 [0.49-0.87]) and low IGFBP-3 serum level (0.71 [0.54-0.93]) remained independent determinants of AF.

CONCLUSIONS:

Low IGF-I and low IGFBP-3 serum levels were independently associated with AF in this elderly population. This result should be confirmed in a longitudinal study to evaluate whether IGF-I and/or IGFBP-3 serum levels are predictive of incident AF.

KEYWORDS:

Atrial fibrillation; Elderly participants; Insulin-like growth factor binding protein-3.; Insulin-like growth factor-I

PMID:
24368776
DOI:
10.1093/gerona/glt206
[Indexed for MEDLINE]
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