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Ann Surg. 2014 Apr;259(4):642-8. doi: 10.1097/SLA.0000000000000361.

Metabolic thrift and the genetic basis of human obesity.

Author information

1
From the Department of Surgery, University of Michigan and Ann Arbor VA Hospital, Ann Arbor, MI.

Abstract

Evolution has molded metabolic thrift within humans, a genetic heritage that, when thrust into our modern "obesogenic" environment, creates the current obesity crisis. Modern genetic analysis has identified genetic and epigenetic contributors to obesity, an understanding of which will guide the development of environmental, pharmacologic, and genetic therapeutic interventions.

PMID:
24368636
PMCID:
PMC4057799
DOI:
10.1097/SLA.0000000000000361
[Indexed for MEDLINE]
Free PMC Article

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