Format

Send to

Choose Destination
See comment in PubMed Commons below
PLoS One. 2013 Dec 18;8(12):e84244. doi: 10.1371/journal.pone.0084244. eCollection 2013.

Novel single nucleotide polymorphism markers for low dose aspirin-associated small bowel bleeding.

Author information

1
Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School, Kurashiki City, Okayama, Japan.
2
Department of Genome Biology, Kinki University Faculty of Medicine, Sayama City, Osaka, Japan.
3
Department of Gastroenterology, Sakakibara Heart Institute of Okayama, Okayama City, Okayama, Japan.

Abstract

BACKGROUND:

Aspirin-induced enteropathy is now increasingly being recognized although the pathogenesis of small intestinal damage induced by aspirin is not well understood and related risk factors have not been established.

AIM:

To investigate pharmacogenomic profile of low dose aspirin (LDA)-induced small bowel bleeding.

METHODS:

Genome-wide analysis of single nucleotide polymorphisms (SNPs) was performed using the Affymetrix DMETâ„¢ Plus Premier Pack. Genotypes of candidate genes associated with small bowel bleeding were determined using TaqMan SNP Genotyping Assay kits and direct sequencing.

RESULTS:

In the validation study in overall 37 patients with small bowel bleeding and 400 controls, 4 of 27 identified SNPs: CYP4F11 (rs1060463) GG (p=0.003), CYP2D6 (rs28360521) GG (p=0.02), CYP24A1 (rs4809957) T allele (p=0.04), and GSTP1 (rs1695) G allele (p=0.04) were significantly more frequent in the small bowel bleeding group compared to the controls. After adjustment for significant factors, CYP2D6 (rs28360521) GG (OR 4.11, 95% CI. 1.62 -10.4) was associated with small bowel bleeding.

CONCLUSIONS:

CYP4F11 and CYP2D6 SNPs may identify patients at increased risk for aspirin-induced small bowel bleeding.

PMID:
24367646
PMCID:
PMC3867469
DOI:
10.1371/journal.pone.0084244
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Public Library of Science Icon for PubMed Central
    Loading ...
    Support Center