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PLoS One. 2013 Dec 18;8(12):e83441. doi: 10.1371/journal.pone.0083441. eCollection 2013.

The association between hypoxia-inducible factor-1 α gene C1772T polymorphism and cancer risk: a meta-analysis of 37 case-control studies.

Author information

1
State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu, China.
2
Department of Oral Radiology, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Abstract

BACKGROUND:

The possible association between HIF-1α C1772T polymorphism and cancer risk has been studied extensively. However, the results were controversial. In order to get a more precise conclusion of this association, a meta-analysis was performed.

METHODS:

A total of 10186 cases and 10926 controls in 37 case-control studies were included in this meta-analysis. Allele and genotypic differences between cases and controls were evaluated. Subgroup analysis by cancer site, ethnicity, source of controls and gender was performed.

RESULTS:

The T allele of HIF-1α gene C1772T was significantly associated with increased cancer risk in three genetic models: TT+CT vs.CC (dominant model OR=1.23, 95%CI=1.03-1.47), TT vs. CT+CC (recessive model OR=2.51, 95%CI=1.54-4.09), TT vs. CC (homozygote comparison OR=2.02, 95%CI=1.21-3.39).In subgroup analysis, the frequency of the T variant was found to be significantly increased in cervical cancer, pancreatic cancer, head and neck cancer, renal cell carcinoma, Asian and female subgroups.

CONCLUSIONS:

Our meta-analysis suggests that the substitution of C allele with T at HIF-1α gene C1772T polymorphism is a risk factor of cancer, especially for cervical, head and neck cancer, pancreatic cancer and renal cell carcinoma. It is also a risk factor of cancer in Asian group as well as in female group.

PMID:
24367595
PMCID:
PMC3867430
DOI:
10.1371/journal.pone.0083441
[Indexed for MEDLINE]
Free PMC Article
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