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J Autism Dev Disord. 2015 Dec;45(12):4015-25. doi: 10.1007/s10803-013-2016-3.

Maternal Infection During Pregnancy and Autism Spectrum Disorders.

Author information

1
Division of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA, 94612, USA. Ousseny.x.zerbo@kp.org.
2
Division of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA, 94612, USA.
3
, Richmond, CA, USA.
4
Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, Davis, CA, USA.
5
The M.I.N.D. Institute, University of California, Davis, Davis, CA, USA.
6
The NIEHS Center for Children's Environmental Health, University of California, Davis, Davis, CA, 95616, USA.

Abstract

We conducted a nested case-control study including 407 cases and 2,075 frequency matched controls to investigate the association between maternal infections during pregnancy and risk of autism spectrum disorders (ASD). Cases, controls, and maternal infections were ascertained from Kaiser Permanente Northern California clinical databases. No overall association between diagnoses of any maternal infection during pregnancy and ASD was observed [adjusted odds ratio (ORadj) = 1.15, 95 % confidence interval (CI) 0.92-1.43]. However, women with infections diagnosed during a hospital admission (ORadj = 1.48, 95 % CI 1.07-2.04), particularly bacterial infections (ORadj = 1.58, 95 % CI 1.06-2.37), were at increased risk of delivering a child with ASD. Multiple infections during pregnancy were associated with ASD (ORadj = 1.36, 95 % CI 1.05-1.78).

KEYWORDS:

Autism spectrum disorder; Maternal infection; Pregnancy

PMID:
24366406
PMCID:
PMC4108569
DOI:
10.1007/s10803-013-2016-3
[Indexed for MEDLINE]
Free PMC Article

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