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Nat Cell Biol. 2014 Jan;16(1):2-9. doi: 10.1038/ncb2897.

Causes and consequences of replication stress.

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1
Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California 94305, USA.

Abstract

Replication stress is a complex phenomenon that has serious implications for genome stability, cell survival and human disease. Generation of aberrant replication fork structures containing single-stranded DNA activates the replication stress response, primarily mediated by the kinase ATR (ATM- and Rad3-related). Along with its downstream effectors, ATR stabilizes and helps to restart stalled replication forks, avoiding the generation of DNA damage and genome instability. Understanding this response may be key to diagnosing and treating human diseases caused by defective responses to replication stress.

PMID:
24366029
PMCID:
PMC4354890
DOI:
10.1038/ncb2897
[Indexed for MEDLINE]
Free PMC Article
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