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Ther Drug Monit. 2014 Jun;36(3):273-7. doi: 10.1097/FTD.0000000000000026.

Severe decrease of cyclosporine levels in a heart transplant recipient receiving the direct thrombin inhibitor argatroban.

Author information

1
CHU Timone Hospital, Marseille, France.

Abstract

This case report is about a suspected interaction between argatroban, a direct thrombin inhibitor, and cyclosporine, which occurred in a 60-year-old patient after a second heart transplantation. We explored 4 possible mechanisms of interaction, which are an analytical interference, an idiopathic hemodilution, an increase of renal and hepatic clearance, and a metabolic drug-drug interaction.

PMID:
24365983
DOI:
10.1097/FTD.0000000000000026
[Indexed for MEDLINE]

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