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Lab Invest. 2014 Feb;94(2):138-49. doi: 10.1038/labinvest.2013.143. Epub 2013 Dec 23.

Recent advances in the investigation of pancreatic inflammation induced by large doses of basic amino acids in rodents.

Author information

1
First Department of Medicine, University of Szeged, Szeged, Hungary.
2
Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, Hungary.
3
Department of Pathology, University of Szeged, Szeged, Hungary.

Abstract

It has been known for approximately 30 years that large doses of the semi-essential basic amino acid L-arginine induce severe pancreatic inflammation in rats. Recently, it has been demonstrated that L-arginine can also induce pancreatitis in mice. Moreover, other basic amino acids like L-ornithine and L-lysine can cause exocrine pancreatic damage without affecting the endocrine parenchyma and the ducts in rats. The utilization of these noninvasive severe basic amino acid-induced pancreatitis models is becoming increasingly popular and appreciated as these models nicely reproduce most laboratory and morphological features of human pancreatitis. Consequently, the investigation of basic amino acid-induced pancreatitis may offer us a better understanding of the pathogenesis and possible treatment options of the human disease.

PMID:
24365745
DOI:
10.1038/labinvest.2013.143
[Indexed for MEDLINE]
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