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Lab Invest. 2014 Feb;94(2):138-49. doi: 10.1038/labinvest.2013.143. Epub 2013 Dec 23.

Recent advances in the investigation of pancreatic inflammation induced by large doses of basic amino acids in rodents.

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First Department of Medicine, University of Szeged, Szeged, Hungary.
Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, Hungary.
Department of Pathology, University of Szeged, Szeged, Hungary.


It has been known for approximately 30 years that large doses of the semi-essential basic amino acid L-arginine induce severe pancreatic inflammation in rats. Recently, it has been demonstrated that L-arginine can also induce pancreatitis in mice. Moreover, other basic amino acids like L-ornithine and L-lysine can cause exocrine pancreatic damage without affecting the endocrine parenchyma and the ducts in rats. The utilization of these noninvasive severe basic amino acid-induced pancreatitis models is becoming increasingly popular and appreciated as these models nicely reproduce most laboratory and morphological features of human pancreatitis. Consequently, the investigation of basic amino acid-induced pancreatitis may offer us a better understanding of the pathogenesis and possible treatment options of the human disease.

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