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J Endocrinol. 2014 Jan 27;220(3):R57-65. doi: 10.1530/JOE-13-0477. Print 2014 Mar.

Determinants of GH resistance in malnutrition.

Author information

1
Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit Street, Bulfinch 457, Boston, Massachusetts 02114, USA.

Abstract

States of undernutrition are characterized by GH resistance. Decreased total energy intake, as well as isolated protein-calorie malnutrition and isolated nutrient deficiencies, result in elevated GH levels and low levels of IGF1. We review various states of malnutrition and a disease state characterized by chronic undernutrition - anorexia nervosa - and discuss possible mechanisms contributing to the state of GH resistance, including fibroblast growth factor 21 and Sirtuin 1. We conclude by examining the hypothesis that GH resistance is an adaptive response to states of undernutrition, in order to maintain euglycemia and preserve energy.

KEYWORDS:

IGF; growth hormone; neuroendocrinology; pituitary

PMID:
24363451
PMCID:
PMC3994591
DOI:
10.1530/JOE-13-0477
[Indexed for MEDLINE]
Free PMC Article

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