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Nat Neurosci. 2014 Feb;17(2):204-6. doi: 10.1038/nn.3609. Epub 2013 Dec 22.

An electroconvulsive therapy procedure impairs reconsolidation of episodic memories in humans.

Author information

1
Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands.
2
1] Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands. [2] Department of Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. [3] Department of Psychiatry and Psychotherapy, University Hospital Essen, Essen, Germany.
3
1] Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands. [2] Department of Psychiatry, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
4
Department of Psychiatry, Rijnstate Hospital, Arnhem, The Netherlands.
5
Laboratory for Clinical Neuroscience, Centre for Biomedical Technology, UPM, Madrid, Spain.
6
1] Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands. [2] Department of Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

Abstract

Despite accumulating evidence for a reconsolidation process in animals, support in humans, especially for episodic memory, is limited. Using a within-subjects manipulation, we found that a single application of electroconvulsive therapy following memory reactivation in patients with unipolar depression disrupted reactivated, but not non-reactivated, memories for an emotional episode in a time-dependent manner. Our results provide evidence for reconsolidation of emotional episodic memories in humans.

PMID:
24362759
DOI:
10.1038/nn.3609
[Indexed for MEDLINE]
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