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Psychiatr Genet. 2014 Feb;24(1):37-41. doi: 10.1097/YPG.0000000000000022.

Are TMEM genes potential candidate genes for panic disorder?

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aTranslational Neuropsychiatry Unit, Department of Clinical Medicine bDepartment of Biomedicine and Centre for Integrative Sequencing (iSEQ), Aarhus University cThe Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH) dResearch Department P, Aarhus University Hospital, Risskov eAmplexa Genetics A/S fDepartment of Clinical Genetics, University of Southern Denmark, Odense gLaboratory of Neuropsychiatry, University of Copenhagen hDepartment of Psychiatry, HS Amager Hospital, Copenhagen University Hospital, Copenhagen, Denmark iDepartment of Psychiatry, the National Hospital, Torshavn, Faroe Islands jMax Planck Institute of Psychiatry, Munich, Germany.


We analysed single nucleotide polymorphisms in two transmembrane genes (TMEM98 and TMEM132E) in panic disorder (PD) patients and control individuals from the Faroe Islands, Denmark and Germany. The genes encode single-pass membrane proteins and are located within chromosome 17q11.2-q12, a previously reported candidate region for PD. Three single nucleotide polymorphisms (rs887231, rs887230 and rs4795942) located upstream and within TMEM132E showed a nominal significant association with PD primarily in the Danish cohort. No nominal significant associations were observed between TMEM98 and PD. Our data indicate that TMEM132E might contribute moderately towards the risk of developing PD.

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