Format

Send to

Choose Destination
Neurosci Lett. 2014 Feb 7;560:107-11. doi: 10.1016/j.neulet.2013.12.026. Epub 2013 Dec 19.

Serum nerve growth factor (NGF) levels in children with attention deficit/hyperactivity disorder (ADHD).

Author information

1
Ankara Pediatric & Pediatric Hematology Oncology Training and Research Hospital, Department of Child and Adolescent Psychiatry, Ankara, Turkey. Electronic address: dresraguney@gmail.com.
2
Yıldırım Beyazıt University Medical Faculty, Department of Child and Adolescent Psychiatry, Ankara, Turkey.
3
Osmangazi University Medical Faculty, Department of Medical Biochemistry, Eskisehir, Turkey.
4
Aksaray University Science Faculty, Department of Biochemistry, Aksaray, Turkey.
5
Ankara Pediatric & Pediatric Hematology Oncology Training and Research Hospital, Department of Child and Adolescent Psychiatry, Ankara, Turkey.
6
Ankara Pediatric & Pediatric Hematology Oncology Training and Research Hospital, Department of Pediatrics, Ankara, Turkey.
7
Ankara Pediatric & Pediatric Hematology Oncology Training and Research Hospital, Department of Medical Biochemistry, Ankara, Turkey.

Abstract

Attention deficit/hyperactivity disorder (ADHD) is the most commonly diagnosed neurobehavioral disorder of childhood. The etiopathogeny of ADHD has not been totally defined. Recent reports have suggested a pathophysiological role of neurotrophins in ADHD. In this study, we evaluated serum levels of nerve growth factor (NGF) in patients with ADHD. The sample population consisted of 44 child or adolescent patients diagnosed with ADHD according to DSM-IV criteria; 36 healthy subjects were included in the study as controls. Venous blood samples were collected, and NGF levels were measured. The mean serum NGF levels of the ADHD patients were significantly higher than those of the controls. Age and gender of the patients were not correlated with serum NGF levels. There were no significant differences in NGF levels among the combined and predominantly inattentive subtypes of ADHD. Our study suggests that there are higher levels of serum NGF in drug naive ADHD patients, and that increased levels of NGF might have an important role in the pathophysiology of ADHD.

KEYWORDS:

ADHD; NGF; Nerve growth factor; Neurodevelopment

PMID:
24361544
DOI:
10.1016/j.neulet.2013.12.026
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center