Format

Send to

Choose Destination
Exp Neurol. 2014 Mar;253:28-30. doi: 10.1016/j.expneurol.2013.12.005. Epub 2013 Dec 18.

Nondystrophic myotonia: challenges and future directions.

Author information

1
Department of Neurology and Neurotherapeutics, UT Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: jaya.trivedi@utsouthwestern.edu.
2
Department of Neurology and Neurotherapeutics, UT Southwestern Medical Center, Dallas, TX 75390, USA.
3
Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA.

Abstract

Non-dystrophic myotonias are rare diseases caused by mutations in skeletal muscle chloride and sodium ion channels with considerable phenotypic overlap between diseases. Common symptoms include muscle stiffness, transitory weakness, fatigue, and pain. Although seldom life-shortening, these myotonias cause life-time disability and affected individuals cannot perform many daily activities. A notable feature of the recessive form of chloride channelopathies is the presence of transient weakness. While there has been considerable progress in skeletal muscle channelopathies with regards to identifying biophysical abnormalities, the mechanism of transient weakness remains unclear. A recent study published in Experimental Neurology (Desaphy et al., 2013) explored this question further by comparing the biophysical properties of 3 chloride channel mutations associated with recessive myotonia congenita, with varying susceptibility to transient weakness. The authors identified a variety of functional defects in channel behavior among the 3 mutations, suggesting that this variability contributes to the differing phenotypes among chloride channelopathies. This commentary discusses nondystrophic myotonias, the results of Desaphy et al., and the treatment challenges in this rare disease.

KEYWORDS:

CLCN1; Myotonia; Non-dystrophic myotonia; Paramyotonia; SCN4A

PMID:
24361411
PMCID:
PMC4078724
DOI:
10.1016/j.expneurol.2013.12.005
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center