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Ann Vasc Surg. 2014 Jul;28(5):1316.e1-6. doi: 10.1016/j.avsg.2013.12.001. Epub 2013 Dec 18.

A unique case report of cerebral amyloid angiopathy with literature review.

Author information

1
Vascular Medicine, Minneapolis Heart Institute, Abbott Northwestern Hospital, Minneapolis, MN. Electronic address: nedaa.skeik@allina.com.
2
Minneapolis Heart Research Foundation, Minneapolis, MN.
3
Interventional Neuroradiology, Neuroscience Institute, Abbott Northwestern Hospital, Minneapolis, MN.
4
Neurosurgery, Abbott Northwestern Hospital, Minneapolis, MN.
5
Pathology, Abbott Northwestern Hospital, Minneapolis, MN.

Abstract

Cerebral amyloid angiopathy (CAA) is a cerebrovascular disease in which β-amyloid peptides are deposited in leptomeningeal, cortical, and subcortical arteries, arterioles, and capillaries. Most individuals with CAA are asymptomatic. However, patients with CAA can present with cognitive impairment and other neurologic deficits caused by vascular wall amyloid deposition leading to hemorrhage. We present a unique case of CAA in a middle-aged woman with a history of cerebral cortex microhemorrhages and cortical edema. Imaging and pathology findings suggested CAA as the main etiology of this presentation. This is a very rare case of CAA coexisting with aneurysmal subarachnoid hemorrhage. Finally, we present a full discussion on the pathogenesis, clinical features, diagnosis, and treatment of CAA.

PMID:
24361381
DOI:
10.1016/j.avsg.2013.12.001
[Indexed for MEDLINE]

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