Format

Send to

Choose Destination
Prog Neuropsychopharmacol Biol Psychiatry. 2014 Apr 3;50:151-6. doi: 10.1016/j.pnpbp.2013.12.006. Epub 2013 Dec 19.

Association analysis of putative cis-acting polymorphisms of interleukin-19 gene with schizophrenia.

Author information

1
Department of Psychiatry, Kobe University Graduate School of Medicine, Kobe, Japan.
2
Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
3
Department of Psychiatry, Kobe University Graduate School of Medicine, Kobe, Japan. Electronic address: hishipon@med.kobe-u.ac.jp.
4
Department of Neuropsychiatry, Kinki University School of Medicine, Osaka, Japan.

Abstract

BACKGROUND:

Genome-wide association studies (GWAS) and gene expression analyses have revealed that single nucleotide polymorphisms (SNPs) associated with multifactorial diseases, such as schizophrenia, are significantly more likely to be associated with expression quantitative trait loci (eQTL). It was recently suggested that an immune system imbalance plays an important role in the pathogenesis of schizophrenia. Interleukin-19 is a novel cytokine that may play multiple roles in immune regulation and various diseases.

METHOD:

We selected eight tag SNPs in the eQTL of the IL-19 gene. Seven of the SNPs are putative cis-acting SNPs. Then, we conducted a case-control study using two independent samples. The first sample comprised 567 schizophrenia patients and 710 controls, and the second sample comprised 677 schizophrenia patients and 667 controls.

RESULT:

We identified the TGAA haplotype as being significantly associated with schizophrenia (p=0.0036 and corrected p=0.0264), although a combined analysis of the TGAA haplotype with the replication samples exhibited a nominally significant difference (p=0.022 and corrected p=0.235).

CONCLUSIONS:

These results suggest that the IL-19 gene might slightly contribute to the genetic risk of schizophrenia. Thus, further research on the association of eQTL SNPs with schizophrenia is warranted.

KEYWORDS:

Haplotype; IL-19; SNP; Schizophrenia; eQTL

PMID:
24361379
DOI:
10.1016/j.pnpbp.2013.12.006
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center