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Phytochemistry. 2014 Feb;98:216-22. doi: 10.1016/j.phytochem.2013.11.012. Epub 2013 Dec 19.

Antibacterial chromene and chromane stilbenoids from Hymenocardia acida.

Author information

  • 1Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc., 1912 Innerbelt Business Center Drive, St. Louis, MO 63114, United States. Electronic address: cstarks@sequoiasciences.com.
  • 2Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc., 1912 Innerbelt Business Center Drive, St. Louis, MO 63114, United States.

Abstract

Six chromene stilbenoids and one chromane stilbenoid were isolated from the African tree Hymenocardia acida. Several were moderately active against methicillin-resistant Staphylococcus aureus clinical isolate MRSA-108, including hymenocardichromanic acid, which was active at 8 μg/ml. None had IC50 values <20 μM in antiproliferation assays against several human cancer cell lines.

KEYWORDS:

Chromane; Chromene; Hymenocardia acida; Methicillin-resistant Staphylococcus aureus (MRSA); Phyllanthaceae

PMID:
24361290
DOI:
10.1016/j.phytochem.2013.11.012
[PubMed - indexed for MEDLINE]
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