Format

Send to

Choose Destination
See comment in PubMed Commons below
Neuron. 2014 Jan 8;81(1):61-8. doi: 10.1016/j.neuron.2013.10.031. Epub 2013 Dec 19.

Pyramidal neurons in prefrontal cortex receive subtype-specific forms of excitation and inhibition.

Author information

1
Department of Psychiatry, University of California, San Francisco, 675 Nelson Rising Lane, San Francisco, CA 94143-0444, USA; Center for Integrative Neuroscience, University of California, San Francisco, 675 Nelson Rising Lane, San Francisco, CA 94143-0444, USA; Sloan-Swartz Center for Theoretical Neurobiology, University of California, San Francisco, 675 Nelson Rising Lane, San Francisco, CA 94143-0444, USA.
2
Department of Psychiatry, University of California, San Francisco, 675 Nelson Rising Lane, San Francisco, CA 94143-0444, USA.
3
Department of Psychiatry, University of California, San Francisco, 675 Nelson Rising Lane, San Francisco, CA 94143-0444, USA; Center for Integrative Neuroscience, University of California, San Francisco, 675 Nelson Rising Lane, San Francisco, CA 94143-0444, USA; Sloan-Swartz Center for Theoretical Neurobiology, University of California, San Francisco, 675 Nelson Rising Lane, San Francisco, CA 94143-0444, USA. Electronic address: vikaas.sohal@ucsf.edu.

Abstract

Layer 5 pyramidal neurons comprise at least two subtypes: thick-tufted, subcortically projecting type A neurons, with prominent h-current, and thin-tufted, callosally projecting type B neurons, which lack prominent h-current. Using optogenetic stimulation, we find that these subtypes receive distinct forms of input that could subserve divergent functions. Repeatedly stimulating callosal inputs evokes progressively smaller excitatory responses in type B but not type A neurons. Callosal inputs also elicit more spikes in type A neurons. Surprisingly, these effects arise via distinct mechanisms. Differences in the dynamics of excitatory responses seem to reflect differences in presynaptic input, whereas differences in spiking depend on postsynaptic mechanisms. We also find that fast-spiking parvalbumin interneurons, but not somatostatin interneurons, preferentially inhibit type A neurons, leading to greater feedforward inhibition in this subtype. These differences may enable type A neurons to detect salient inputs that are focused in space and time, while type B neurons integrate across these dimensions.

PMID:
24361076
PMCID:
PMC3947199
DOI:
10.1016/j.neuron.2013.10.031
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center