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Acta Histochem. 2014 May;116(4):588-95. doi: 10.1016/j.acthis.2013.11.005. Epub 2013 Dec 20.

Honokiol suppresses TNF-α-induced migration and matrix metalloproteinase expression by blocking NF-κB activation via the ERK signaling pathway in rat aortic smooth muscle cells.

Author information

1
Department of Cardiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, People's Republic of China; Department of Cardiology, The General Hospital of Benxi Iron and Steel Co. Ltd., The Fifth Affiliated Hospital of China Medical University, Benxi, Liaoning 117000, People's Republic of China.
2
Department of Cardiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, People's Republic of China.
3
Department of Cardiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, People's Republic of China. Electronic address: hoojian@live.com.

Abstract

Honokiol, a small-molecule polyphenol derived and isolated from the Chinese medicinal herb Magnolia officinalis, has been shown to possess a wide range of pharmacological activities. In the present study, we aimed to investigate the effects of honokiol on tumor necrosis factor-α (TNF-α)-induced migration in rat aortic smooth muscle cells (RASMCs). We found that honokiol inhibited TNF-α-induced RASMC proliferation and migration in a dose-dependent manner. At the molecular level, pretreatment with honokiol blocked TNF-α-induced protein expression of matrix metalloproteinase (MMP)-2 and MMP-9, nuclear factor (NF)-κB activation, and extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation. Moreover, NF-κB inhibitor (BAY 11-7028) and ERK inhibitor (U0126) also mimicked the inhibitory effects of honokiol in TNF-α-treated RASMCs. In conclusion, these results indicate that honokiol suppresses TNF-α-induced migration and MMP expression by blocking NF-κB activation via the ERK signaling pathway in RASMCs. Our findings support honokiol as a promising novel agent for the prevention and treatment of atherosclerosis.

KEYWORDS:

ERK; Honokiol; Matrix metalloproteinase-2/9; Migration; Nuclear factor-κB; Vascular smooth muscle cells

PMID:
24360976
DOI:
10.1016/j.acthis.2013.11.005
[Indexed for MEDLINE]

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