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Metabolism. 2014 Mar;63(3):382-91. doi: 10.1016/j.metabol.2013.11.005. Epub 2013 Nov 12.

Walnut-enriched diet reduces fasting non-HDL-cholesterol and apolipoprotein B in healthy Caucasian subjects: a randomized controlled cross-over clinical trial.

Author information

1
Division of Endocrinology and Metabolism at Medical Department 2, University of Munich Medical Center, Munich, Germany.
2
Division of Metabolic and Nutritional Medicine at Dr. von Hauner Children's Hospital, University of Munich Medical Center, Munich, Germany.
3
Helmholtz Zentrum Muenchen, Institute for Health Economics and Healthcare Management, Neuherberg, Germany.
4
Division of Endocrinology, Diabetes, and Metabolism at Beth Israel Deaconess Medical Center, Boston, MA, USA.
5
Division of Endocrinology and Metabolism at Medical Department 2, University of Munich Medical Center, Munich, Germany. Electronic address: klaus.parhofer@med.uni-muenchen.de.

Abstract

BACKGROUND:

Walnut consumption is associated with reduced risk of coronary heart disease (CHD).

OBJECTIVE:

We assessed the effect of walnuts on lipid and glucose metabolism, adipokines, inflammation and endothelial function in healthy Caucasian men and postmenopausal women ≥50years old.

DESIGN:

Forty subjects (mean±SEM: age 60±1years, BMI 24.9±0.6kg/m(2); 30 females) were included in a controlled, cross-over study and randomized to receive first a walnut-enriched (43g/d) and then a Western-type (control) diet or vice-versa, with each lasting 8weeks and separated by a 2-week wash-out. At the beginning and end of each diet phase, measurements of fasting values, a mixed meal test and an assessment of postprandial endothelial function (determination of microcirculation by peripheral artery tonometry) were conducted. Area under the curve (AUC), incremental AUC (iAUC) and treatment×time interaction (shape of the curve) were evaluated for postprandial triglycerides, VLDL-triglycerides, chylomicron-triglycerides, glucose and insulin.

RESULTS:

Compared with the control diet, the walnut diet significantly reduced non-HDL-cholesterol (walnut vs. control: -10±3 vs. -3±2mg/dL; p=0.025) and apolipoprotein-B (-5.0±1.3 vs. -0.2±1.1mg/dL; p=0.009) after adjusting for age, gender, BMI and diet sequence. Total cholesterol showed a trend toward reduction (p=0.073). Fasting VLDL-cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides and glucose, insulin, HOMA-IR, and HbA1c did not change significantly. Similarly, fasting adipokines, C-reactive protein, biomarkers of endothelial dysfunction, postprandial lipid and glucose metabolism and endothelial function were unaffected.

CONCLUSION:

Daily consumption of 43g of walnuts for 8weeks significantly reduced non-HDL-cholesterol and apolipoprotein-B, which may explain in part the epidemiological observation that regular walnut consumption decreases CHD risk.

KEYWORDS:

Endothelial function; Glucose; Lipids; Nuts; Peripheral artery tonometry

PMID:
24360749
DOI:
10.1016/j.metabol.2013.11.005
[Indexed for MEDLINE]
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