Send to

Choose Destination
See comment in PubMed Commons below
Psychosomatics. 2014 May-Jun;55(3):243-51. doi: 10.1016/j.psym.2013.09.001. Epub 2013 Dec 18.

Coronary plaque volume and composition assessed by computed tomography angiography in patients with late-onset major depression.

Author information

Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Denmark. Electronic address:
Department of Cardiology, Aarhus University Hospital, Skejby, Denmark.
Department of Cardiology, Odense University Hospital, Odense, Denmark.
Department of Internal Medicine II, University of Erlangen, Erlangen, Germany.
Biomedical Imaging Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA.
Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Denmark.



Depression is a stronger predictor for the onset of or death from clinical coronary artery disease than traditional cardiovascular risk factors. The association between depression and coronary artery disease has previously been investigated in non-contrast enhanced computed tomography studies with conflicting results. The aim of this study was to further elucidate the depression-coronary artery disease relation by use of coronary computed tomography angiography.


The calcified and noncalcified coronary plaque volumes were determined by semiautomatic volumetric quantification in 28 patients with late-onset major depression and 27 controls. The calcified plaque proportion, i.e., the calcified plaque volume divided by the total plaque volume, was used to assess the plaque composition.


There was no statistically significant difference in the total (p = 0.48), calcified (p = 0.15), and noncalcified (p = 0.62) plaque volume between patients and controls, and the total plaque volume did not predict depression, odds ratio = 1.001 [95% confidence interval: 0.999-1.003; p = 0.23]. However, the calcified plaque proportion was twice as high in patients compared with controls (14% vs. 7%, p = 0.044). Correspondingly, having depression was associated with an increased calcified plaque proportion of 11.3 [95% confidence interval: 2.63-20.1; p = 0.012] percentage points after adjustment for demographics and cardiovascular risk factors.


The proportion of the total coronary plaque volume that was calcified was significantly higher in patients with late-onset major depression than in controls, indicating a difference in plaque composition.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center