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Neuron. 2013 Dec 18;80(6):1341-4. doi: 10.1016/j.neuron.2013.12.001.

A variability-generating circuit goes awry in a songbird model of the FOXP2 speech disorder.

Author information

1
Department of Neurobiology and Behavior, W121 Corson Mudd Hall, Cornell University, Ithaca, NY 14853, USA.
2
Department of Neurobiology and Behavior, W121 Corson Mudd Hall, Cornell University, Ithaca, NY 14853, USA. Electronic address: jesse.goldberg@cornell.edu.

Abstract

FOXP2 mutations cause a monogenic speech disorder in humans. In this issue of Neuron, Murugan et al. (2013) show that knockdown of FoxP2 in the songbird basal ganglia causes abnormal vocal variability and excess bursting in a frontal cortical nucleus.

PMID:
24360538
PMCID:
PMC4119750
DOI:
10.1016/j.neuron.2013.12.001
[Indexed for MEDLINE]
Free PMC Article

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