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Zhonghua Yi Xue Za Zhi. 2013 Sep 17;93(35):2810-2.

[Effects of different antihypertensive strategies on reversing urinary albumin excretion].

[Article in Chinese]

Author information

1
Heart Center, Peking University People's Hospital, Beijing 100044, China.
2
Heart Center, Peking University People's Hospital, Beijing 100044, China. Email: nlsun@263.net.

Abstract

OBJECTIVE:

To explore the effects of different antihypertensive strategies on blood pressure and urinary albumin excretion in patients with hypertension and microalbuminuria.

METHODS:

For this multi-center, randomized, positively controlled clinical trial, a total of 531 patients with mild-to-moderate essential hypertension and microalbuminuria were enrolled. They were divided randomly into calcium channel blocker (CCB), angiotensin II receptor antagonist (ARB) and CCB+ARB groups. The whole treatment period was 6 months.

RESULTS:

According to ANOVA analysis, the post-therapeutic urinary albumin level decreased 20.6, 27.6 and 30.9 mg/L in CCB, ARB and CCB+ARB groups respectively (P = 0.067). And the extents of urinary albumin reduction were 31.1 and 6.6 mg/L in patients with controlled and uncontrolled blood pressure respectively (P < 0.001).

CONCLUSION:

Effective antihypertensive therapy is a key for decreasing urinary albumin excretion in hypertensive patients. As compared with calcium antagonists, ARB-containing regimens appear to be better in reducing urinary albumin.

PMID:
24360178
[Indexed for MEDLINE]

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