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Nanomedicine (Lond). 2014;9(8):1263-75. doi: 10.2217/nnm.13.93. Epub 2013 Dec 20.

Radiofrequency-triggered release for on-demand delivery of therapeutics from titania nanotube drug-eluting implants.

Author information

1
School of Chemical Engineering, The University of Adelaide, Engineering North Building, SA 5005, Australia.

Abstract

AIM:

This study aimed to demonstrate radiofrequency (RF)-triggered release of drugs and drug carriers from drug-eluting implants using gold nanoparticles as energy transducers.

MATERIALS & METHODS:

Titanium wire with a titania nanotube layer was used as an implant loaded with indomethacin and micelles (tocopheryl PEG succinate) as a drug and drug carrier model. RF signals were generated from a customized RF generator to trigger in vitro release.

RESULTS & DISCUSSION:

Within 2.5 h, 18 mg (92%) of loaded drug and 14 mg (68%) of loaded drug carriers were released using short RF exposure (5 min), compared with 5 mg (31%) of drug and 2 mg (11%) of drug carriers without a RF trigger. Gold nanoparticles can effectively function as RF energy transducers inside titania nanotubes for rapid release of therapeutics at arbitrary times.

CONCLUSION:

The results of this study show that RF is a promising strategy for triggered release from implantable drug delivery systems where on-demand delivery of therapeutics is required.

KEYWORDS:

drug-eluting implant; gold nanoparticle; micelle; noninvasive drug delivery; polymer; radiofrequency; titania nanotube; triggered drug release; water-insoluble drug

PMID:
24359550
DOI:
10.2217/nnm.13.93
[Indexed for MEDLINE]
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