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J Comp Pathol. 1987 Jan;97(1):61-72.

Nuclear segmentation, ultrastructure, and cytochemistry of blood cells from dogs with Pelger-Huët anomaly.


Nuclear segmentation, ultrastructural features and cytochemical staining reactions of blood cells from 7 dogs with the heterozygous form of Pelger-Huët (P-H) anomaly were investigated. Significant nuclear hyposegmentation of granulocytes, monocytes and megakaryocytes was found, indicating a common stem cell defect in the nuclear segmentation or lobulation process. Neutrophils and eosinophils from female P-H dogs lacked sex chromatin drumsticks. Other than the suggestion of nuclear hyposegmentation and the presence of coarse heterochromatin, no ultrastructural abnormalities were discerned. Cytochemical staining by a-naphthyl acetate esterase, alkaline phosphatase, naphthol ASD chloroacetate esterase, periodic acid-Schiff, peroxidase and Sudan black B techniques gave similar results for P-H and control dog leukocytes and platelets.

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