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EMBO Rep. 2014 Jan;15(1):103-9. doi: 10.1002/embr.201337371. Epub 2013 Dec 15.

Type 1 metabotropic glutamate receptors (mGlu1) trigger the gating of GluD2 delta glutamate receptors.

Author information

1
Centre National de la Recherche Scientifique (CNRS) UMR 8119 Neurophysics and Physiology Laboratory, Université Paris Descartes, Paris, France.

Abstract

The orphan GluD2 receptor belongs to the ionotropic glutamate receptor family but does not bind glutamate. Ligand-gated GluD2 currents have never been evidenced, and whether GluD2 operates as an ion channel has been a long-standing question. Here, we show that GluD2 gating is triggered by type 1 metabotropic glutamate receptors, both in a heterologous expression system and in Purkinje cells. Thus, GluD2 is not only an adhesion molecule at synapses but also works as a channel. This gating mechanism reveals new properties of glutamate receptors that emerge from their interaction and opens unexpected perspectives regarding synaptic transmission and plasticity.

PMID:
24357660
PMCID:
PMC4303454
DOI:
10.1002/embr.201337371
[Indexed for MEDLINE]
Free PMC Article

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