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J Gambl Stud. 2015 Mar;31(1):295-7. doi: 10.1007/s10899-013-9433-2.

Pathological gambling induced by dopamine antagonists: a case report.

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1
Psychiatric Hospital of the University of Basel, Wilhelm Klein-Strasse 27, 4012, Basel, Switzerland.

Abstract

Pathological gambling is defined as inappropriate, persistent, and maladaptive gambling behaviour. It is a non-pharmacological addiction classified as an impulse control disorder. However, pathological gambling has been associated with dopamine agonist use. Here we report of a 28-year-old man with a first major depressive episode and a post-traumatic stress disorder who has been treated with a combination of the serotonine/noradrenaline reuptake inhibitor duloxetine and the tricyclic antidepressant maprotiline. The administration of antipsychotic flupentixole (up to 7 mg) turned this slight online poker gambler into an excessive gambler. Only after the discontinuation of the antidopaminergic agents and the switch to bupropion did this gambling behaviour stop which suggests a causal relationship between dopamine antagonists and pathological gambling.

PMID:
24356928
DOI:
10.1007/s10899-013-9433-2
[Indexed for MEDLINE]
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