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Coron Artery Dis. 2014 Mar;25(2):172-85. doi: 10.1097/MCA.0000000000000072.

Comprehensive overview of definitions for optical coherence tomography-based plaque and stent analyses.

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aDepartment of Cardiovascular Medicine, Policlinico A. Gemelli, Catholic University of the Sacred Heart bInterventional Cardiology Unit, San Giovanni Addolorata Hospital and C.L.I. Foundation, Rome cCentre for Inherited Cardiovascular Diseases, Transplant Research Area, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy dHarvard Medical School, Beth Israel Deaconess Medical Center eHarvard Medical School, Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts fUniversity Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio gZena and Michael A. Weiner Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.


Optical coherence tomography (OCT) is the current state-of-the-art intracoronary imaging modality that allows visualization of detailed morphological characteristics of both atherosclerotic plaque and stent. So far, three expert review documents have been released for standardization of OCT image analysis. In the real world, a variety of definitions are being used by different groups and by different core laboratories to analyze OCT findings because of different clinical/procedural contexts in which OCT research has been carried out. This comprehensive overview is aimed to summarize different applicable definitions used by different research groups in plaque and stent analysis using OCT. In addition, it presents readers with a panoramic view to select the best definition of OCT measurement for one's own study purpose. We divided this review article into two parts: Part I - Plaque analysis, and Part II - Stent analysis. The plaque analysis section summarizes the definitions of plaque composition, rupture, erosion, protruding calcific nodules, macrophages, microvessels, and cholesterol crystal. The stent analysis section includes the classification of stent struts, features of neointimal hyperplasia, and other stent-related findings such as tissue protrusion, thrombus, intrastent, and stent edge dissections. In each case of controversy, an explanation for the specific context is provided.

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