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Therapie. 2013 Nov-Dec;68(6):385-92. doi: 10.2515/therapie/2013066. Epub 2013 Dec 20.

[Opioid therapy for chronic noncancer pain: retrospective analysis of patients hospitalized for withdrawal].

[Article in French]

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Département de Pharmacologie médicale et Toxicologie, Centre d'Addictovigilance, Hôpital Lapeyronie, CHRU Montpellier, UM1, Montpellier, France.
Centre d'Évaluation et de Traitement de la Douleur (CETD), Hôpital Saint-Éloi, CHRU Montpellier, UM1, Montpellier, France.



The prescription of opioids for the treatment of chronic non-cancer pain (CNCP) is not recommended for all of them, and can expose the patients to a benefit/risk ratio unfavorable. The objective of this study was to evaluate the management of patients hospitalized at the centre for evaluation and treatment of pain for opioid withdrawal, their outcome during hospitalization.


This is a retrospective descriptive study. The medical record of each patient was consulted to identify relevant data (demographics, treatments at the entrance and discharge of hospitalization, comorbidities, rating scale of pain).


During the study period (3 years), 53 patients (64% of women), with a median age of 52 years, were included. Pain was mainly back pain and neck pain (52%). Morphine (43%) and fentanyl (42%) were the most frequently used opioids. At admission, 62% of patients had a depressive state. At hospital discharge, withdrawal was total in 18 patients (34%) and a total improvement of pain was observed for 19% of them.


In this study, 57% of patients received, at admission to hospital, an opioid other than morphine in the treatment of CNCP. The management of pain offered by the pain clinic led to a total or partial opioid withdrawal in 94% of patients.

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