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Exp Cell Res. 2014 Mar 10;322(1):202-7. doi: 10.1016/j.yexcr.2013.12.008. Epub 2013 Dec 16.

Staphylococcal enterotoxin C2 promotes osteogenesis and suppresses osteoclastogenesis of human mesenchymal stem cells.

Author information

1
School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, PR China; Guang zhou Institute of Advanced Technology, Chinese Academy of Sciences, PR China.
2
School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, PR China; Guangdong Province Key Laboratory of Medical Molecular Diagnosis, Department of Biochemistry, Guangdong Medical College, Dongguan, PR China.
3
Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Hong Kong, PR China.
4
School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, PR China.
5
Shenzhen Xielian Gene Engineering Co., Ltd., Shenzhen, PR China.
6
Guang zhou Institute of Advanced Technology, Chinese Academy of Sciences, PR China.
7
School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, PR China; Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, PR China. Electronic address: zhangjf06@cuhk.edu.hk.
8
School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, PR China; Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Hong Kong, PR China. Electronic address: hkung@cuhk.edu.hk.

Abstract

As a super-antigen, staphylococcal enterotoxin C2 (SEC2) stimulates the release of massive inflammatory cytokines such as interferon-gamma (IFN-γ), interleukin-1 (IL-1) and interleukin-2 (IL-2) which are documented to implicate osteoblast differentiation. In the present study, SEC2 was found to significantly improve the osteoblast differentiation by up-regulating BMP2 and Runx2/Cbfa1 expression. Interferon (IFN)-inducible gene IFI16, a co-activator of Runx2/Cbfa1, was also activated by SEC2 in the osteoblast differentiation. In addition, exogenous introduction of SEC2 stimulated OPG expression and suppressed RANKL, suggesting suppression of osteoclastogenesis in hMSCs. Therefore, our results displayed that SEC2 plays an important role in the commitment of MSC to the osteoblast and it might be a potential new therapeutic candidate for bone regeneration.

KEYWORDS:

Human mesenchymal stem cell; Osteoblast; Osteoclast; Staphylococcal enterotoxin C2; Superantigen

PMID:
24355808
DOI:
10.1016/j.yexcr.2013.12.008
[Indexed for MEDLINE]
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