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Enferm Infecc Microbiol Clin. 2014 Dec;32(10):647-53. doi: 10.1016/j.eimc.2013.10.013. Epub 2013 Dec 17.

[Carbapenem antibiotics in hospitalised paediatric patients. Adherence to a therapeutic protocol].

[Article in Spanish]

Author information

1
Unidad de Patología Infecciosa e Inmunodeficiencias de Pediatría, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, España.
2
Unidad de Patología Infecciosa e Inmunodeficiencias de Pediatría, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, España. Electronic address: fmoraga@acmcb.es.
3
Servicio de Farmacia, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, España.
4
Servicio de Microbiología, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, España.
5
Servicio de Medicina Preventiva y Epidemiología, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, España.

Abstract

OBJECTIVE:

To describe the use of carbapenems in children hospitalised outside intensive care and onco-haematology units, and assess adherence to a therapeutic protocol.

PATIENTS AND METHODS:

A retrospective observational study was conducted on the use of carbapenems between January 2009 and December 2010. The study included children with a community-acquired infectious disease or a health care-associated infectious disease, and who were admitted to paediatric areas of the Vall d'Hebron University Hospital (Barcelona, Spain), other than intensive care, neonatology and onco-haematology units. Clinical data were collected and antibiotic consumption data were provided by the Pharmacy Department.

RESULTS:

A total of 51 episodes fulfilled the inclusion criteria. Carbapenem as initial empirical treatment was indicated in 31.4%, and applied as rescue therapy in the remainder. The instructions of the protocol were adhered to in 70.6% of the empirical and 87.5% of the targeted prescriptions (77.6% overall). A better match was found for empirical carbapenem in patients with a previous admission or underlying condition. Factors such as diagnosis, age or antibiotic use prior to admission did not affect the empirical indication of carbapenem.

CONCLUSIONS:

The establishment of a treatment protocol with carbapenem indications in our centre since 2007 has yielded significantly better results on the appropriateness of the prescription than those obtained in other studies.

KEYWORDS:

Antimicrobial use; Carbapenems; Carbapenémicos; Community-acquired infection and health care-associated infection; Infección comunitaria y relacionada con asistencia sanitaria; Paediatrics; Pediatría; Uso de antimicrobianos

PMID:
24355607
DOI:
10.1016/j.eimc.2013.10.013
[Indexed for MEDLINE]
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