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Prog Neuropsychopharmacol Biol Psychiatry. 2014 Apr 3;50:74-82. doi: 10.1016/j.pnpbp.2013.12.005. Epub 2013 Dec 16.

The association of 5-HTR2A-1438A/G, COMTVal158Met, MAOA-LPR, DATVNTR and 5-HTTVNTR gene polymorphisms and borderline personality disorder in female heroin-dependent Chinese subjects.

Author information

1
Department of Social Medicine, School of Public Health, Central South University, Changsha, China; Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, China.
2
Department of Social Medicine, School of Public Health, Central South University, Changsha, China.
3
Department of Psychiatry, West China Hospital, Sichuan University, Chengdu, China.
4
Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, China.
5
Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, China. Electronic address: weihao57@gmail.com.

Abstract

OBJECTIVE:

To explore the association between the 5-HTR2A-1438A/G, COMTVal158Met, MAOA-LPR, DATVNTR and 5-HTTVNTR polymorphisms with co-morbid borderline personality disorder (BPD) in female heroin-dependent patients.

SUBJECTS AND METHODS:

In a case control study, we compared the polymorphic distributions of 5-HTR2A-1438A/G, COMTVal158Met, MAOA-LPR, DATVNTR and 5-HTTVNTR in 296 female heroin-dependent patients (including 61 patients with BPD and 235 without BPD) and 101 normal females by genotypes, alleles, and interaction between genes.

RESULTS:

Female heroin-dependent subjects with BPD have lower frequency of the high activity allele (L: 4 repeats (4R)) of MAOA-LPR than those female heroin-dependent subjects without BPD, and have higher 5-HTTVNTR 10R/10R genotype frequency than normal female controls, with adjusted P-value<0.05 (after adjusted for multiple testing by 1000-fold permutation tests) respectively. By MDR (Multifactor Dimensionality Reduction) analyses, the interactive effects between MAOA-LPR and 5-HTTVNTR, and among MAOA-LPR, 5-HTTVNTR and rs6311 were close to the significance level (P=0.05) in predicting the risk of co-morbidity of BPD and heroin dependence relative to normal female controls, with 1000-fold permutation testing P-value<0.06 however >0.05 respectively.

CONCLUSION:

5-HTTVNTR and MAOA-LPR may have independent predictive effects on co-morbid BPD in female heroin-dependent patients; the gene-gene interactions between MAOA-LPR and 5-HTTVNTR, and among MAOA-LPR, 5-HTTVNTR and rs6311 might also be involved in the etiology of this co-morbidity.

KEYWORDS:

Association study; Borderline personality disorder; Co-morbidity; Gene polymorphism; Heroin dependence

PMID:
24355137
DOI:
10.1016/j.pnpbp.2013.12.005
[Indexed for MEDLINE]

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