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Fertil Steril. 2014 Mar;101(3):676-82. doi: 10.1016/j.fertnstert.2013.11.022. Epub 2013 Dec 17.

Progesterone level at oocyte retrieval predicts in vitro fertilization success in a short-antagonist protocol: a prospective cohort study.

Author information

1
Magee-Women's Hospital, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; Magee-Women's Research Institute, Pittsburgh, Pennsylvania.
2
Magee-Women's Hospital, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; Magee-Women's Research Institute, Pittsburgh, Pennsylvania; Fertility Center, York, Pennsylvania.
3
University of Pittsburgh, Pittsburgh, Pennsylvania.
4
Magee-Women's Hospital, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
5
Magee-Women's Research Institute, Pittsburgh, Pennsylvania.
6
Magee-Women's Hospital, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Electronic address: wakian@mail.magee.edu.

Abstract

OBJECTIVE:

To evaluate the distribution of P levels on the day of oocyte retrieval as it relates to pregnancy outcome in an antagonist protocol, which may be at higher risk for elevated P levels.

DESIGN:

Prospective cohort study.

SETTING:

Academic IVF center.

PATIENT(S):

One hundred eighty-six women undergoing controlled ovarian hyperstimulation with an antagonist protocol.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

Implantation, pregnancy, and spontaneous abortion rates were collected.

RESULT(S):

Implantation rate (positive hCG 14 days after ET) and pregnancy rate were significantly higher when the P level was <12 ng/mL on the day of oocyte retrieval. Miscarriage rates were higher when the P level was ≥12 ng/mL, although this did not reach statistical significance.

CONCLUSION(S):

Elevated P on the day of oocyte retrieval is associated with significantly lower implantation and ongoing pregnancy rates. This is the first study to date to both uncover the distribution of P on the day of oocyte retrieval in an antagonist cycle and determine the impact an elevation may have on pregnancy outcome.

KEYWORDS:

Progesterone level; antagonist cycle; oocyte retrieval

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