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Tissue Antigens. 2014 Jan;83(1):27-31. doi: 10.1111/tan.12265.

HLA frequencies and associations in cystic fibrosis.

Author information

1
Department of Paediatrics & Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Maastricht University Medical Centre, Maastricht, the Netherlands.

Abstract

Cystic fibrosis (CF) is classically attributed to the dysfunction of the single CF transmembrane conductance regulator gene. The incidence of human leukocyte antigen (HLA) polymorphisms in different CF-associated diseases raises the question of an unequal distribution of HLA genotypes in CF. This study aimed to evaluate HLA gene frequencies and possible associations in CF patients compared with a control population. Frequencies of HLA-DRB1, HLA-DQA1 and HLA-DQB1, performed by intermediate resolution typing using Luminex sequence-specific oligonucleotide, and epitope counts were similar in 340 CF patients when compared with 400 control subjects. In conclusion, HLA-DRB1, -DQA1 and -DQB1 do not seem to influence susceptibility to CF. Whether HLA plays a role in the severity of CF disease needs to be investigated.

KEYWORDS:

HLA antigens; HLA-DQ alpha-chains; HLA-DQ beta-chains; HLA-DRB1 chains; cystic fibrosis; cystic fibrosis transmembrane conductance regulator

PMID:
24355005
DOI:
10.1111/tan.12265
[Indexed for MEDLINE]

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