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Nanomedicine (Lond). 2014 Jan;9(1):135-51. doi: 10.2217/nnm.13.194.

Surface modification of nonviral nanocarriers for enhanced gene delivery.

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Life Sciences NRC Human Health Therapeutics Portfolio, Building Montréal-Royalmount, National Research Council Canada, Montréal, QC, H4P 2R2, Canada.


Biomedical nanotechnology has given a new lease of life to gene therapy with the ever-developing and ever-diversifying nonviral gene delivery nanocarriers. These are designed to pass a series of barriers in order to bring their nucleic acid cargo to the right subcellular location of particular cells. For a given application, each barrier has its dedicated strategy, which translates into a physicochemical, biological and temporal identity of the nanocarrier surface. Different strategies have thus been explored to implement adequate surface identities on nanocarriers over time for systemic delivery. In that context, this review will mainly focus on organic nanocarriers, for which these strategies will be described and discussed.

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