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FEMS Microbiol Rev. 2014 Mar;38(2):228-53. doi: 10.1111/1574-6976.12055. Epub 2014 Jan 16.

Cell polarization in budding and fission yeasts.

Author information

1
Department of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.

Abstract

Polarization is a fundamental cellular property, which is essential for the function of numerous cell types. Over the past three to four decades, research using the best-established yeast systems in cell biological research, Saccharomyces cerevisiae (or budding yeast) and Schizosaccharomyces pombe (or fission yeast), has brought to light fundamental principles governing the establishment and maintenance of a polarized, asymmetric state. These two organisms, though both ascomycetes, are evolutionarily very distant and exhibit distinct shapes and modes of growth. In this review, we compare and contrast the two systems. We first highlight common cell polarization pathways, detailing the contribution of Rho GTPases, the cytoskeleton, membrane trafficking, lipids, and protein scaffolds. We then contrast the major differences between the two organisms, describing their distinct strategies in growth site selection and growth zone dimensions and compartmentalization, which may be the basis for their distinct shapes.

KEYWORDS:

Rho GTPases; cytoskeleton; fungi; membrane trafficking; polarization; yeast

PMID:
24354645
DOI:
10.1111/1574-6976.12055
[Indexed for MEDLINE]
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